Category Archives: New Research

Identifying SAM children: MUAC and/or Weight-for-Height

Grellety and Golden (2018) have published 3 new papers which challenge the use of MUAC solely for identification of children with Severe Acute Malnutrition. Access the full papers below: Severely malnourished children with a low weight-for-height have a higher mortality than those with a low mid-upper-arm-circumference: I. Empirical data demonstrates Simpson’s paradox link Severely malnourished […]

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Papers on nutritious complementary feeding to improve nutrition and prevent childhood undernutrition

These papers are part of Supplement of MCN on Policy, Program and Innovation in Complementary Feeding sponsored by Sight and Life. They are free access and provide evidence from research on nutritious complementary feeding for the prevention of childhood undernutrition. Links to the papers are available via Sight and Life website at Supplement for MCN […]

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Treatment of severe and moderate acute malnutrition in low- and middle-income settings: a systematic review, meta-analysis and Delphi process

This systematic review evaluates the effectiveness of interventions for SAM including the World Health Organization (WHO) protocol for inpatient management and community-based management with ready-to-use-therapeutic food (RUTF), as well as interventions for MAM in children under five years in low- and middle-income countries. Link

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Specially formulated foods for treating children with moderate acute malnutrition in low- and middle-income con tries (Review)

The study evaluated the safety and effectiveness of different types of specially formulated foods for children with moderate acute malnutrition in low- and middle-income countries, and to assess whether foods complying or not complying with specific nutritional compositions, such as the WHO technical specifications, are safe and effective. Download

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Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial

A study among Pakistani children has found that the use of micronutrient powders reduces iron-deficiency. In this cluster-randomised trial, Soofi and colleagues concluded that the excess burden of diarrhoea and respiratory morbidities associated with micronutrient powder use and the very small effect on growth recorded suggest that a careful assessment of risks and benefits must […]

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Do Children with Uncomplicated Severe Acute Malnutrition Need Antibiotics? A Systematic Review and Meta-Analysis

A recent systematic review has concluded that the evidence underlying current antibiotic recommendations for uncomplicated SAM is weak. Susceptibility studies favour amoxicillin over cotrimoxazole. However, given that these antibiotics have side-effects, costs, and risks as well as benefits, their routine use needs urgent testing. With reliable monitoring, we believe that there is sufficient equipoise for […]

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Antibiotics as Part of the Management of Severe Acute Malnutrition

Indi Trehan, M.D., M.P.H., D.T.M.&H., Hayley S. Goldbach, Sc.B., Lacey N. LaGrone, M.D., Guthrie J. Meuli, B.S., Richard J. Wang, M.D., Kenneth M. Maleta, M.B., B.S., Ph.D., and Mark J. Manary, M.D. N Engl J Med 2013; 368:425-435January 31, 2013DOI: 10.1056/NEJMoa1202851 Abstract Background Severe acute malnutrition contributes to 1 million deaths among children annually. Adding […]

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Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

ABSTRACT Kwashiorkor, an enigmatic form of severe acute malnutrition, is the consequence of inadequate nutrient intake plus additional environmental insults. To investigate the role of the gut microbiome, we studied 317 Malawian twin pairs during the first 3 years of life. During this time, half of the twin pairs remained well nourished, whereas 43% became […]

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Iron-containing micronutrient powder supplmentation increases haemoglobin concentrations but not the risk of infectious morbidity

In another randomized, double-blind, placebo-controlled, non-inferiority safety trial using a 2-mo course of daily iron Micronutrient Powder (MNP), or placebo powder (PP) conducted in 268 Bangladeshi children aged 12-24 mo with MAM (weight-for-age z score ≤ -2) and a hemoglobin concentration between 70 and 110 g/L, Lemaire and colleagues have reported that iron MNP is […]

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Diagnostic performance of visible severe wasting for identifying severe acute malnutrition

A research has found that visible severe wasting failed to detect approximately half of the children admitted to hospital with severe acute malnutrition diagnosed anthropometrically The cross sectional study sought to determine the diagnostic value of visible severe wasting in identifying severe acute malnutrition among children aged 6 to 59.9 months admitted to one rural […]

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